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New Insights into the Genetic Etiology of Alzheimer's Disease and Related Dementias

Genetic Factors Associated with Alzheimer's Disease

Genetic variations play a significant role in the development of Alzheimer's disease. One of the most common forms of Alzheimer's, late-onset Alzheimer's, typically occurs after the age of 65 and is linked to specific genetic factors.

Rare Genetic Variants Related to Late-Onset Alzheimer's

Researchers have identified rare coding variants in two genes, PSEN1 and PSEN2, in families with multiple cases of late-onset Alzheimer's. These variants are believed to contribute to the disease's development.

Importance of Modeling Alzheimer's Disease

Understanding the genetic causes of Alzheimer's disease is crucial for studying the disease's mechanisms and developing effective treatments. Researchers use models of Alzheimer's disease to investigate the pathophysiology of the disease and identify potential therapeutic targets.